XU
Worth 9 points before any premium square, and the highest-scoring of the 96 — tied with 5 others.
Nothing extends XU. No letter in front of it and no letter behind it makes a three-letter word, which makes it one of only 2 dead ends on the list. That is a limitation when you are building and a tool when you are not: a word nobody can extend is the safe thing to put next to a premium square you would rather your opponent could not reach.
Every hook
No letter in front of XU makes a word.
No letter after XU makes a word.
How often you can actually play it
Out of an opening rack, 1.57% of the time you hold the letters for XU outright, the 2nd least likely of 96. Counting a blank as whichever letter is missing lifts that to 5.46%, though spending one of the two blanks on a two-letter word is rarely the play. Exact hypergeometrics over the 100-tile bag, not a simulation.